Malicious software are usually obfuscated to avoid detection and resist analysis. When new malware is encountered, such obfuscations have to be penetrated or removed (``deobfuscated'') in order to understand the internal logic of the code and devise countermeasures. This paper discusses a generic approach for deobfuscation of obfuscated executable code. Our approach does not make any assumptions about the nature of the obfuscations used, but instead uses semantics-preserving program transformations to simplify away obfuscation code. We have applied a prototype implementation of our ideas to a variety of different kinds of obfuscation, including emulation-based obfuscation, emulation-based obfuscation with runtime code unpacking, and return-oriented programming. Our experimental results are encouraging and suggest that this approach can be effective in extracting the internal logic from code obfuscated using a variety of obfuscation techniques, including tools such as Themida that previous approaches could not handle.