In many client-facing applications, a vulnerability in any part can compromise the entire application. This paper describes the design and implementation of Passe, a system that protects a data store from unintended data leaks and unauthorized writes even in the face of application compromise. Passe automatically splits (previously shared-memory-space) applications into sandboxed processes. Passe limits communication between those components and the types of accesses each component can make to shared storage, such as a backend database. In order to limit components to their least privilege, Passe uses dynamic analysis to learn data and control-flow relationships between database queries and previous query results, and it then strongly enforces those relationships. Our prototype of Passe acts as a drop-in replacement for the Django web framework. By running eleven unmodified, off-the-shelf applications in Passe, we demonstrate its ability to provide strong security guarantees — Passe correctly enforced 96% of the applications’ policies — with little additional overhead. Additionally, in the web-specific setting of the prototype, we also mitigate the cross-component effects of cross-site scripting (XSS) attacks by combining browser HTML5 sandboxing techniques with our automatic component separation.